Welcome to the Mabb Lab!

-Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mabb. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. JBC, J Biol Chem. 2024 Mar 27;300(5). Link

-George AJ, Wei W, Pyaram DN, Gomez M, Shree N, Kadirvelu J, Lail H, Wanders D, Murphy AZ, Mabb AM. Gordon Holmes syndrome model mice exhibit age and sex-specific disruptions in cognitive and proprioceptive function. eNeuro, In Press. Link

-Lail H, Mabb AM, Parent MB, Pinheiro P, Wanders D. Effects of Dietary Methionine Restriction on Cognition in Mice. Nutrients. 2023 Nov 29;15(23):4950. Link

-Mabb AM. A Hier”Arc”ical Pathway for Memory Updating. Biol Psychiatry. 2023 Nov 1;94(9):686-688.

-Ghane MA, Wei W, Yakout DW, Allen ZD, Miller CL, Dong B, Fang N, Yang JJ, Mabb AM. Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling. Front Cell Neurosci. 2023 Mar 14;17:1091324. Link

-Wei W, Yount ST, Allen ZD, Bechdol KF, Xia W, Mo H, Mabb AM. The mevalonate suppressor δ-tocotrienol increases AMPA receptor-mediated neurotransmission. Biochem Biophys Res Commun. 2023 Jan 1;638:112-119.  Link

-George AJ, Dong B, Lail H, Gomez M, Hoffiz YC, Ware C, Fang N, Murphy AZ, Hrabovszky E, Wanders D, Mabb AM. The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis, iScience. 2022 May 10;25(6):104386.  Link

-Deng X, Yao XQ, Berglund K, Dong B, Ouedraogo D, Ghane MA, Zhuo Y, McBean C, Wei ZZ, Gozem S, Yu SP, Wei L, Fang N, Mabb AM, Gadda G, Hamelberg D, Yang JJ. Tuning Protein Dynamics to Sense Rapid Endoplasmic-Reticulum Calcium Dynamics. Angew Chem Int Ed Engl. 2021 Aug 26.  Link

-Mabb AM. Historical perspective and progress on ubiquitination at glutamatergic synapses.  Neuropharmacology. 2021 Jun28:108690.  Link

-Reddish FN, Miller CL, Deng X., Dong B, Patel AA, Ghane MA, Mosca B, McBean C, Wu S, Solntsev KM, Zhuo Y, Gadda G, Fang N, Cox DN, Mabb AM, Treves S, Zorzato F, Yang JJ. Rapid subcellular Calcium responses and dynamics by Calcium sensor G-CatchER+. iScience. 2021 Feb 3;24(3):102129.  Link

-Yakout DW, Shree N, Mabb AM. Effect of pharmacological manipulations on Arc function. Current Research in Pharmacology and Drug Discovery, 2, 100013 (2020).  Link 

-Fragola G, Mabb AM, Taylor-Blake B, Niehaus J, Chronister W, Mao H, Simon J, Yuan H, Li Z, McConnell MJ, Zylka MJ.  Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.  Nat Commun, 11, 1962 (2020).  Link

-Ghane MA*, Yakout DW*, Mabb AM. A High-content Assay for Monitoring AMPA Receptor Trafficking. J Vis Exp. 2019 Jan 28;(143). doi: 10.3791/59048. PubMed PMID: 30741265. Link

-Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM#, Corrêa SAL#.  The temporal dynamics of Arc expression regulate cognitive flexibility.  Neuron. 2018 May 24. Link 

-George AJ, Hoffiz YC, Charles AJ, and Mabb AM.  A comprehensive atlas of E3 ubiquitin ligase mutations in neurological disorders.  Frontiers in Genetics. 2018 Feb 14;9:29. doi: 10.3389/fgene.2018.00029. eCollection 2018.  Link

-Mabb AM# and Ehlers MD#.  Arc ubiquitination in synaptic plasticity.  Seminars in Cell and Developmental Biology.  2018 May;77:10-16. doi: 10.1016/j.semcdb.2017.09.009. Epub 2017 Sep 7.  Link

-Mabb AM, Simon JM, King IF, Lee HM, An LK, Philpot BD, Zylka MJ.  Topoisomerase 1 regulates gene expression in neurons through cleavage complex-dependent and -independent mechanisms.  PLOS ONE.  2016.  11(5): e0156439.  Doi:10.1371/journal.pone.0156439.  ​Link​

-Niedringhaus M, Dumitru R, Mabb AM, Wang Y, Philpot BD, Allbritton NL, Taylor AM.  Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons.  Scientific Reports.  2015 Feb 10;5:8353.  Link

-Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ.  Topoisomerase 1 inhibition reversibly impairs synaptic function.  Proceedings of the National Academy of Sciences.  2014 Dec 2;111(48):17290-5.  Link

-Mabb AM*, Je HS*, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, and Ehlers MD.  Triad3A regulates synaptic strength by ubiquitination of Arc.  Neuron.  2014 Jun 18;82(6):1299-316.  Link

-King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ.  Topoisomerases Facilitate Transcription of Long Genes Linked to Autism.  Nature.  2013 Sep 5;501(7465):58-62.  Link

-Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD.  Trans-Synaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1.  Neuron.  2012 Oct;76(2):396-409.  Featured cover article.  Link

-Huang H-S*, Allen JA*, Mabb AM, King IF, Miriyala JL, Taylor-Blake B, Sciaky N, Dutton JW, Lee H-M, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD.  Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.  Nature.  2011 Dec 21;481(7380):185-9.  Link

-Lee MH, Mabb AM, Gill GB, Yeh ET, and Miyamoto S.  NF-kappaB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress.  Molecular Cell.  2011 Jul 22;43(2):180-91. Link

-Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA.  A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 MAP kinase/MAPKAP-2 responses to DNA damage.  Molecular and Cellular Biology.  2011 Jul;31(14):2774-86.  Link

-Mabb AM*, Judson MC*, Zylka MJ, Philpot BD.  Angelman Syndrome:  Insights into Genomic Imprinting and Neurodevelopmental Phenotypes.  Trends in Neuroscience.  2011 Jun;34(6):293-303.  Review.  Featured cover article.  Link

-Mabb AM and Ehlers MD.  Ubiquitination in postsynaptic function and plasticity.  Annual Review of Cell and Developmental Biology.  2010 Nov 10;26:179-210.  Link

-Mabb AM and Miyamoto S.  SUMO and NF-kappaB Ties.  Cell Mol Life Sci. 2007 Aug;64(15):1979-96. Review.  Link

-Mabb AM, Wuerzberger-Davis SM, Miyamoto S.  PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.  Nature Cell Biology.  2006 Sep:8(9):986-93.  Link​

-Wu ZH, Mabb A, Miyamoto S.  PIDD: A Switch Hitter.  Cell. 2005 Dec 16:123(6):980-2.  Link

-Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS.  Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.  Proceedings of the National Academy of Sciences.  2004 Apr 20;101(16):5898-903.  Link

# = Corresponding author

​* = co-first author