Welcome to the Mabb Lab!

The E3 ubiquitin ligase RNF216 contains a linear ubiquitin chain-determining-like domain that functions to regulate dendritic arborization and dendritic spine type in hippocampal neurons.

​​Jayashree Kadirvelu#, Savannah E. Jacobs#, Ruochuan Liu#, Antoinette J. Charles, Jun Yin*, Angela M. Mabb*

https://www.biorxiv.org/content/10.1101/2023.10.19.563080v1

A differential effect for tau isoforms and mutants in decreasing the stability of Arc. 

Dina W. Yakout, Ankit Shroff, Zachary D. Allen, Taras Y. Nazarko, Angela M. Mabb

​https://www.biorxiv.org/content/10.1101/2022.12.15.520620v1

​Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling.

MA Ghane, ZD Allen, CL Miller, B Dong, N Fang, JJ Yang, AM Mabb

https://www.biorxiv.org/content/10.1101/2022.09.02.506383v1

The E3 ubiquitin ligase RNF216/TRIAD3 is a central regulator of the hypothalamic-pituitary-gonadal axis.

Arlene J. George, Yarely C. Hoffiz, Christopher Ware, Bin Dong, Ning Fang, Erik Hrabovszky, Angela M. Mabb

https://www.biorxiv.org/content/10.1101/2021.03.21.436306v1